Pachyonychia Congenita is a rare, genetic disorder of keratinization,

 Medically reviewed by Dr Rehaam Ali Khan 


 affecting the skin and nails. This disorder can be present at birth or may appear during the first decade of life. It affects both sexes and occurs worldwide, but is most commonly seen in people with Northern European ancestry.

The primary symptoms of Pachyonychia Congenita are hard calluses on the palms of the hands and soles of the feet, as well as thickening and discoloration of the nails. People with this condition also experience blistering on areas such as the back of their hands or feet and sometimes on their ears, neck, eyes, mouth or tongue. They may also have rough patches of skin or lesions on their scalp that cause hair loss. In some cases, it can lead to deformities in the fingernails or toenails, as well as dental enamel defects or missing teeth.

Since Pachyonychia Congenita is a genetic disorder, it is inherited from one's parents and there is no cure for it yet. However, treatments such as antibiotics for bacterial infections that may occur in conjunction with this condition and keratolytics to help reduce calluses can provide some relief. Other treatments involve controlling the signs and symptoms such as regular trimming of nails to reduce discomfort caused by nail growth irregularities; using salicylic acid solutions to remove excess keratin build-up; covering blisters with sterile gauze dressings; using sunscreen to protect skin; using lotion regularly to keep skin moisturized; wearing soft shoes that don't rub against calluses; avoiding activities that cause friction; and maintaining proper oral hygiene to prevent dental problems associated with Pachyonychia Congenita.

Living with Pachyonychia Congenita can be difficult for those affected by this rare condition since there are few treatments available and much about it still remains unknown. If you suspect that you or someone you know has this condition, speak to a medical professional for an accurate diagnosis so they can discuss treatment options with you.